Check MBHD2022 Abstract Book HERE.



  • Each half-day block will include two thematic areas, with each thematic area built on a TED-style talk to review the current state of knowledge and knowledge gaps to be addressed. TED-style talks are delivered without notes, from memory, although they are not spontaneous; rather, they are scripted and carefully rehearsed.  The speaker is never behind a lectern and the supporting slides are highly visual with images of exceptional quality.  The theme will not focus on the invited scientist’s personal research experience but rather lay the foundation for the subsequent talks in the session by including representative data and discoveries from all research scientists who have moved the area forward.  A TED guideline is: “Thou Shalt Not Simply Trot Out thy Usual Shtick.” We expect the TED-talk speakers to educate, inspire, motivate and captivate the audience. 

  • The invited talks that follow TED-style talks will be 10-minute talks thematically linked to the specific topic.

  • Selected sessions will include panel discussions to engage the audience, facilitates dialogue and to promote interactivity. 


To learn more about topics, click on session titles


MBHD2022 Program


Tuesday May 24, 2022





  11:00 - 14:00

REGISTRATION at The Museum of Natural History (17 N Clinton St, Iowa City, IA 52240)

Welcome and Opening Remarks 14:00 - 14:20
Richard SMITH, MBHD2020 Chair

Session 1: The Expanding Genetic and Genomic Landscapes of Deafness



14:20 - 14:40

Tom Friedman

Naughty Noncoding Variant or Nicely in Disequilibrium?

14:40 - 14:55 Mustafa Tekin Characterization of MINAR2 as a Novel Autosomal Recessive Deafness Gene
14:55 - 15:10 Jonathan Lin Mutations in the Unfolded Protein Response Regulator Atf6 Cause Sensorineural Hearing Loss and Impairment of the Organ of Corti
15:10 - 15:25 Miles Klimara De Novo Mutations are a Common Cause of Genetic Hearing Loss
15:25 - 15:40 Elvis Twumasi Aboagye Age Estimates of GJB2-p.(Arg143Trp) Founder Variant in Hearing Impairment in Ghana, suggest Multiple Independent Origins across Populations

Coffee Break: 15:40 - 16:00

Session 2: Molecular Basis of Mechanotransduction Machinery 


David COREY & Ulrich MUELLER

16:00 - 16:20

Peter Barr-Gillespie

Fifty Years of Hair-Cell Mechanotransduction

16:20 - 16:35 Brian McDermott Asymmetric Mechanotransduction by Hair Cells of the Zebrafish Lateral Line
16:35 - 16:50 Nicolas Grillet LOXHD1 is required for Mechanotransduction and localizes at the Lower Tip-Link insertion point
16:50 - 17:05 Xufeng Qiu The Tetraspan LHFPL5 Establishes Force Sensitivity of the Mechanotransduction Channel of Cochlear Hair Cells
17:05 - 17:20 Isabel Aristizábal-Ramírez Deafness-associated Variant of the Calcium and Integrin-Binding Protein 2 (CIB2) Slows Down Force Transmission to the Mechanotransducer Channels in Mammalian Auditory Hair Cells
  17:20 - 17:35 Marcos Sotomayor Towards an Atomistic Model of the Inner-Ear Transduction Apparatus

Panel Discussion

17:35 - 18:00   Richard SMITH, Tom FRIEDMAN, Peter BARR-GILLESPIE, Hannie KREMER, Hela AZAIEZ, David COREY,  Ulrich MUELLER
  18:00 - 19:00
Poster Setup at the Iowa Memorial Union Main Lounge (125 N Madison St, Iowa City, IA 52245)


Reception at The Museum of Natural History: 19:30 - 22:00


Wednesday May 25, 2022





Light Breakfast at the Conference Venue

Session 3: Molecular Biology of Cochlear Development


Doris WU & Karen ELLIOTT

8:00 - 8:20

Andrew Groves

Molecular Biology of Cochlear Development: Problems, Puzzles and Paradoxes in Making the World’s Best Hearing Aid

8:20 - 8:35 Sandra De Haan Effects of Jag1-Mediated Notch Activation in Inner Ear Patterning: Insights from the Nodder Mouse Model for Alagille Syndrome
8:35- 8:50 Angelika Doetzlhofer The RNA-binding Protein TRIM71 Regulates Pro-Sensory Cell Behavior in the Mammalian Cochlea
8:50 - 9:05 Suraj Chakravarthy The Role of Ezrin and Radixin Proteins in “Blooming” of Nascent Stereocilia in Auditory Hair Cells
9:05 - 9:20 Basile Tarchini Heterotrimeric G Protein Signaling Regulates the Graded Height Architecture of the Stereocilia Bundle
9:20 - 9:35 Benjamin Perrin A Novel Population of Short Actin Filaments at Stereocilia Tips and a Tip-Down Widening Mechanism
9:35 - 9:50 Botond Banfi A Novel Regulator of Hair Cell Maturation Enhances ATOH1 Activity in the Hearing Organ

Coffee Break: 9:50 - 10:15

Session 4: Transcriptome Profiling of the Auditory System



10:15 - 10:35

Lisa Goodrich

10:35 - 10:50 Kevin Rose Diversity of Otic Mesenchyme Cells During Cochlear Development
10:50 - 11:05 Joerg Waldhaus Opposing Gradients of Retinoic Acid and Sonic Hedgehog Signaling Specify the Tonotopic Axis in the Murine Cochlea
11:20 - 11:35 Yoshitomo Ueda Defining the Developmental Trajectory of Prosensory Cells in Human Inner Ear Organoids at Single-Cell Resolution
11:35 - 11:50 David He Transcriptomic Differences between Adult Mouse Cochlear and Vestibular Hair Cells
11:50 - 12:05 Matthew Kelly Development of Neuronal Phenotypes in the Spiral Ganglion

Panel Discussion

12:05 - 12:30   Andrew GROVES, Lisa GOODRICH, Doris WU, Bernd FRITZSCH, Angelika DOETZLHOFER & Matt KELLY 

Lunch: 12:30 - 13:45 at Iowa Memorial Union Main Lounge (125 N Madison St, Iowa City, IA 52245)

Session 5: Poster Social and Speed-Dating

13:45- 15:45

Even number Posters: 13:45-14:45

Odd number Posters: 14:45-15:45

Poster presentations and one-on-one meetings with Senior Scientists


16:00 - 17:00 At MacBride Hall Auditorium (Conference Venue) The Deafness Variation Database (DVD)           
17:00 - 18:30 At MacBride Hall Auditorium (Conference Venue)  The gene Expression Analysis Resource (gEAR)     

Free Night


Thursday May 26, 2022





Light Breakfast at the Conference Venue

Session 6: Pathological Mechanisms Underlying Deafness (1)


Sandrine MARLIN & Amal ABU RAYAN

8:00 - 8:20

Karen Steel

A Thousand Ways to Lose Your Hearing

8:20 - 8:35 Miguel Angel Moreno-Pelayo Insights into the Pathophysiology of DFNA44 Hearing Loss Associated with CCDC50 Variants
8:35 - 8:50 Yehree Kim Auditory Phenotype and Histopathologic Findings of a Mutant Nlrp3 Expression Mouse Model
8:50 - 9:05 Isabelle Roux Interaction of SLC26A4 with Adaptor Protein (AP-2) Complex in Mitochondria-Rich Cells of the Endolymphatic Sac
9:05 - 9:20 Maria Lachgar-Ruiz Exploring the Pathological Mechanisms of miR-96 Mutations in the Inner Ear
9:20 - 9:35 Sherylanne Newton Neuroplastin Genetically Interacts with Cadherin 23 and Np55 is Sufficient for Cochlear Hair Cell Function and Hearing
Coffee Break: 9:35 - 10:00

Session 7: Pathological Mechanisms Underlying Deafness (2)



10:00 - 10:20 Ben Warren Age and Noise Affect Distinct Physiological Processes in the Auditory System
10:20 - 10:35 Ben Gansemer Neurodegeneration in the Cochlea After Hair Cell Loss is Due to an Immune Response
10:35 - 10:50 Allen F Ryan The Role of Middle Ear Epithelial Cells in the Resolution of Otitis Media
10:50 - 11:05 Bernd Fritzsch Neurons and Hair Cells Require Lmx1a/b for Normal Brainstem Development
11:05 - 11-20 Mark Rutherford Central and Peripheral Auditory Function in APP/PS1 Mice
11:20 - 11:35 Elisa Martelletti Reversal of Hearing Loss in Spns2 Mutant Mice

Panel Discussion

11:35 - 12:15   Karen STEEL, Mike BOWL, Aziz EL AMRAOUI, Sandrine MARLIN, Katie KINDT, Allen RYAN, Miguel MORENO-PELAYO
Lunch: 12:30 - 14:00 Iowa Memorial Union Main Lounge (125 N Madison St, Iowa City, IA 52245)

Session 8: Hair cell damage, repair and regeneration


Yehoash RAPHAEL and Tejbeer KAUR

14:00 - 14:20

Stefan Heller

VICs - Very Important Cells

14:20 - 14:35 Allison Coffin Ototoxic Potential of COVID-19 Therapeutics
14:35 - 14:50 Jinkyung Kim In Vivo Real-Time Imaging Reveals Megalin As Aminoglycoside Transporter Into Cochlea Whose Inhibition Is Otoprotective
14:50 - 15:05 A. Catalina Velez-Ortega TRPA1 Activation in Non-Sensory Supporting Cells Contributes to the Regulation of Cochlear Sensitivity after Acoustic Trauma

15:05 - 15:20

Nesrine Benkafadar Protease-Activated Receptor is Essential for Mitotic Basilar Papilla Hair Cell Regeneration
15:20 - 15:35 Melissa McGovern Regeneration of Hair Cells in the Mature Mouse Cochlea Following Reprogramming with Atoh1, Gfi1, and Pou4f3
Coffee Break: 15:35 - 16:00

Session 9: Deafness: from Gene to Therapeutics



15:40 - 16:00

Zheng-Yi Chen

A New Era in Precision Medicine for Genetic Hearing Loss

16:00 - 16:15 Michael Anne Gratton Sparsentan Protects from Hearing Loss, Improves Kidney Function & Prolongs Lifespan in Alport Mice with Developed Pathology
16:15 - 16:30 Danielle Lenz Evaluating miR-Target Sites as a Strategy to Allow AAV Vector-based De-targeting of Gene Expression in the Inner Ear
16:30 - 16:45 Kathrin Kusch Characterization of Promoter Expression in Type 1 Spiral Ganglion Neurons in vitro and in vivo
16:45 - 17:00 Osama Tarabichi Development of novel helper dependent adenoviral vectors for inner ear gene therapy
17:00 - 17:15 Olga Shubina-Oleinik Dual Vector Gene Therapy Restores Hearing in a Mouse Model of DFNB16 Hearing Loss

Panel Discussion

17:15 - 18:00   Stefan HELLER, Yehoash RAPHAEL, Xue ZHONG LIU, Tejbeer KAUR, Ellen REISINGER, Mark WARCHOL 

BBQ Dinner at The Celebration Farm (5 Buses will be available to bring attendees to the Barn and back)



Friday May 27, 2022





Light Breakfast at the Conference Venue

Session 10: Precision and Translational Medicine for Deafness

Moderators: Cynthia MORTON and Kevin BOOTH

8:00 - 8:20

Christine Petit

Hearing Medicine in The Light of Scientific Advances: Dream or Reality?

8:20 - 8:35 Ryan Carlson Genetic and Phenotypic Heterogeneity of Childhood-Onset Hearing Loss and Implications for Success of Cochlear Implants
8:35 - 8:50 Erik de Vrieze Development of a Genetic Therapy for DFNA21 using Allele-specific Antisense Oligonucleotides
8:50 - 9:05 Ellen Reisinger A Dual-AAV Approach with Human Otoferlin cDNA Rescues Hearing in Otof- Knock-Out Mice for at Least 10 Months
9:05 - 9:20 Maryna Ivanchenko Mini-PCDH15 Gene Therapy Rescues Hearing in a Mouse Model of Usher Syndrome Type 1F

Coffee Break 9:20 - 9:40

Session 11: Emerging Themes and Methods

Moderators: Hainan LANG and Jacob NEEF

9:40 - 10:00


Emerging Technologies in Hearing Research

10:00 - 10:15 Rick Nelson Wnt Signaling Promotes Cell Caudalization and Inner Ear Differentiation in Mouse Stem Cell-Derived Organoids
10:15 - 10:30 Karen Elliott Thompson Determining the Molecular Mechanisms of Inner Ear Sensory Neuron Guidance to Direct a Novel Approach of Ear Transplantation
10:30 - 10:45 Tejbeer Kaur Macrophages Promote Repair of Damaged Ribbon Synapses and SGN survival Following Noise-Induced Cochlear Synaptopathy
10:45 - 11:00 John Brigande Initial Phenotypic Characterization of a Rhesus Macaque Model of Usher Syndrome Type 1B

Panel Discussion

11:00 - 11:45   Christine PETIT, Eri HASHINO, Cynthia MORTON, Kevin BOOTH, Ambroise WONKAM, John BRIGANDE, Hainan LANG

Poster Blitz and Award Ceremony

11:45 - 12:15    

Closing Remarks

12:15 - 12:30 Richard SMITH & Hela AZAIEZ

Boxed Lunches will be available at the conference venue: 12:30 - 14:00